EU H2020 FET-Open Pan3DP
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The EU H2020 FET-Open Pan3DP project was a multi-disciplinary consortium with the goal of developing an innovative bioprinting approach for generating pancreatic tissue. The project brings together experts in developmental biology, computational biology, organ modelling and tissue engineering, from both academia and industry.
Promoting Research Aims
This project was centred on explaining the research aims and strategy of the Pan3DP Consortium as well as its research outcomes which was highlighted in the Pan3DP Conference. Pancreatic diseases including diabetes, pancreatic cancer and acute and chronic pancreatitis affects global populations with diabetes alone responsible for over 4.2 million deaths [1].
Despite the obvious need for new therapies to treat these diseases, developing new therapies is hampered by limited access to in vivo pancreatic tissue which reliably models the organ itself. The consortium's pioneering work will advance the field of regenerative medicine by developing the first 3D bioprinting set-up to fabricate pancreatic tissue.
RESEARCH AIM 1:
To expand and unify the knowledge of 3D in vivo architecture of the developing pancreas
"We will generate systematic information documenting the 3D pancreatic tissue organization and topological relationships of the epithelium with the surrounding mesenchyme and vasculature."
RESEARCH AIM 2:
To develop bioprinting solutions for engineering pancreatic tissue units
"We have built an interdisciplinary team that will work together to develop a unique approach for the biofabrication of pancreatic modules that recapitulate native pancreatic tissue-architecture."
RESEARCH AIM 3:
To establish conditions for in vitro differentiation and maturation of the bioprinted pancreatic tissue
"Our aim here is to establish conditions for in vitro differentiation and maturation of the bioprinted pancreatic tissue and to extensively study the tissue after the organ-printing process."
Promoting Shared Research Data
The Pan3DP consortium aims to make their sequencing and imaging data open access and freely available to the science community and the general public.
Knowledge and innovation leading to growth are central to the Europe 2020 strategy for a smart, sustainable and inclusive economy. Contributing to the advancement of research, particularly in the fields of diabetes, developmental biology and regenerative medicine, the Pan3DP consortium are committed to making RNA-sequencing and imaging data generated during the project openly accessible.
Promoting Consortium Conferences
Hosted in London, the Pan3DP Conference 'Pan3DP Con: Engineering Multicellular Tissues' brought together international delegates in developmental biology, computational biology, organ modelling and tissue engineering to discuss their work towards creating 3D-bioprinted tissue as part of the EU-PAN3DP Consortium and included expert speakers and poster sessions.
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Conference Organisers
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Francesca M. Spagnoli (KCL) - King’s College London, United Kingdom
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Limor Landsman (TAU) - Tel Aviv University, Tel Aviv, Israel
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Christophe Pierreux (DDI) - de Duve Institute-UCL, Brussels, Belgium
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Dagmar Iber (ETH) - ETH, Basel, Switzerland
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Shulamit Levenberg (TEC) - Technion Israel Institute of Technology, Haifa, Israel
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Fabien Guillemot, Poietis (POI) - Bioparc Bordeaux Métropole, France
Promoting Consortium Members
"By combining the strengths and expertise of each of our project partners, we will be able to achieve our aim of fabricating pancreatic tissue using 3D bioprinting. There are three main themes of research in this project which all feed into our goal: Developmental Cell Biology, Computational Biology and 3D Bioprinting."
Project Partners
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